Dynamic contrast-enhanced magnetic resonance imaging in paediatric brain tumours systematically reviewed

Area of Science:

• Neuro-oncology
• Medical Imaging
• Paediatric Oncology

Background:

• Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantifies blood-brain barrier permeability.
• Its role in paediatric brain tumours requires clarification.

Purpose of the Study:

• Evaluate DCE-MRI efficacy in differentiating paediatric brain tumours.
• Assess its utility in monitoring tumour progression.
• Summarize technical implementation for clinical guidance.

Main Methods:

• Systematic literature search of PubMed and Web of Science.
• Inclusion of original articles on DCE-MRI utility in paediatric brain tumours.
• Risk of bias assessment using a modified QUADAS-2 tool.

Main Results:

• Nine studies (2008-2025) included, with sample sizes from 6-72.
• Limited success in differentiating low-grade from high-grade tumours (3/6 studies).
• Better discrimination between distinct histologies observed.
• Variable technical execution and non-compliance with guidelines noted.
• Prognostic potential for survival prediction was not promising.

Conclusions:

• DCE-MRI may aid in distinguishing between specific paediatric brain tumour entities.
• General discrimination between low- and high-grade lesions remains uncertain.
• Further research with technical standardization is crucial for exploring prognostic value.