Long-term Outcomes in Gallbladder Cancer Patients Treated with Curative-Intent Resection: Adjuvant Chemotherapy
Lin-Yi Yu1, Zhi-Peng Liu1, Hao-Ran Zhu2
1Department of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.
Annals of Surgical Oncology
|April 1, 2026
Summary
Adjuvant chemotherapy after gallbladder cancer surgery significantly improves survival and reduces recurrence. This approach offers a better prognosis for patients compared to observation alone.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Background:
- Gallbladder cancer (GBC) presents challenges in achieving long-term survival post-resection.
- The role of adjuvant chemotherapy in improving outcomes for resected GBC remains an area of active investigation.
Purpose of the Study:
- To evaluate the impact of adjuvant chemotherapy versus observation on recurrence and survival in patients undergoing curative-intent resection for GBC.
- To compare overall survival (OS) and progression-free survival (PFS) between treatment groups.
Main Methods:
- A multicenter cohort of 604 GBC patients treated with curative-intent resection (2014-2021) was analyzed.
- Propensity score matching was used to balance baseline characteristics between observation and chemotherapy groups.
- Kaplan-Meier curves, log-rank tests, and multivariable Cox regression were employed to assess survival outcomes.
Main Results:
- Adjuvant chemotherapy was associated with significantly higher 3-year overall survival (OS) and progression-free survival (PFS) rates compared to observation post-resection.
- Multivariable analysis confirmed that chemotherapy is an independent predictor of improved OS and PFS in GBC patients.
Conclusions:
- Adjuvant chemotherapy following curative-intent resection for gallbladder cancer is a valuable strategy.
- This treatment can effectively reduce the risk of disease recurrence and prolong patient survival.
Keywords:
Adjuvant chemotherapyGallbladder cancerOverall survivalProgression-free survivalPropensity score matchingMore Related Videos
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