Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Airway, Skin Color, and Use of Accessory Muscles01:30

Assessment of Airway, Skin Color, and Use of Accessory Muscles

1.9K
A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...
1.9K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

1.8K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of Hearing Impairment Among Young Adults.

The Israel Medical Association journal : IMAJ·2026
Same author

The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.

Journal of personalized medicine·2026
Same author

The effect of the COVID-19 pandemic on surgical volume and residency training program in pediatric otolaryngology.

BMC medical education·2026
Same author

The Reliability of Intraoperative Frozen Section for Glottic Lesions Suspected of Early Malignancy.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Solar urticaria successfully treated with remibrutinib.

The journal of allergy and clinical immunology. In practice·2026
Same author

Iatrogenic Obstructive Sialadenitis of the Parotid and Submandibular Glands Following Facial Rejuvenation.

Aesthetic plastic surgery·2026

Related Experiment Video

Updated: Apr 2, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
03:05

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

1.7K

Predicting Laryngeal Involvement in Pemphigus Vulgaris Using a Clinical Risk Score.

Dean Ariel1,2, Nir Tsur1,3, Daniel Mimouni1,4

  • 1Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.

JAMA Dermatology
|April 1, 2026
PubMed
Summary

A new clinical prediction model helps identify patients with pemphigus vulgaris who need laryngoscopy. This tool aids in safely deferring the procedure for low-risk individuals and prioritizing high-risk cases.

More Related Videos

Point-of-Care Ultrasound: A Review of Ultrasound Parameters for Predicting Difficult Airways
08:21

Point-of-Care Ultrasound: A Review of Ultrasound Parameters for Predicting Difficult Airways

Published on: April 7, 2023

2.7K
Image Acquisition using Portable Sonography for Emergency Airway Management
07:31

Image Acquisition using Portable Sonography for Emergency Airway Management

Published on: September 28, 2022

3.2K

Related Experiment Videos

Last Updated: Apr 2, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
03:05

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

1.7K
Point-of-Care Ultrasound: A Review of Ultrasound Parameters for Predicting Difficult Airways
08:21

Point-of-Care Ultrasound: A Review of Ultrasound Parameters for Predicting Difficult Airways

Published on: April 7, 2023

2.7K
Image Acquisition using Portable Sonography for Emergency Airway Management
07:31

Image Acquisition using Portable Sonography for Emergency Airway Management

Published on: September 28, 2022

3.2K

Area of Science:

  • Dermatology
  • Otolaryngology
  • Medical Informatics

Background:

  • Deep laryngeal involvement in pemphigus vulgaris affects 10-40% of patients, posing significant airway risks.
  • Current detection via laryngoscopy is invasive and uncomfortable, with lacking criteria for its necessity.

Purpose of the Study:

  • To develop and internally validate a clinical prediction model for deep laryngeal involvement in pemphigus vulgaris patients.
  • To establish evidence-based criteria for selecting patients requiring laryngoscopic examination.

Main Methods:

  • Retrospective cohort study of 247 pemphigus vulgaris patients (2015-2022).
  • Development of a prediction model using Firth penalized logistic regression and bootstrap validation.
  • Primary outcome: deep laryngeal involvement assessed by flexible fiber-optic laryngoscopy.

Main Results:

  • 19.8% of patients had deep laryngeal involvement.
  • Key predictors identified: hoarseness (OR 2.50), dysphagia (OR 6.22), and Pemphigus Disease Area Index score with sex interaction.
  • A scoring system stratified patients into low (0%), intermediate (15.3%), and high (66.7%) risk categories.
  • Model achieved AUC of 0.78 and negative predictive value of 92.6%.

Conclusions:

  • The developed clinical prediction model demonstrates good discrimination and a high negative predictive value.
  • This tool can help identify low-risk patients who may safely avoid laryngoscopy.
  • External validation is recommended to confirm its utility in clinical practice for prioritizing evaluations.