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Related Concept Videos

Prochirality02:05

Prochirality

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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Chirality in Nature02:30

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Fischer Projections02:18

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Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
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Stereoisomerism of Cyclic Compounds02:33

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In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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A Micropatterning Assay for Measuring Cell Chirality
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Exploiting virtual three-dimensional asymmetry for planar intrinsic chirality.

Byeong Je Jeon, Yu Geun Ki, Hyeon Woo Jeon

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    Researchers achieved strong intrinsic chirality using a simple planar metasurface, avoiding complex 3D fabrication. This breakthrough enables enhanced optical chirality applications with a novel substrate-induced asymmetry approach.

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    Area of Science:

    • Photonics and Metamaterials
    • Nanotechnology
    • Optical Chirality

    Background:

    • Achieving intrinsic chirality at optical wavelengths typically requires complex 3D nanofabrication or loss engineering.
    • Existing methods present significant challenges in terms of fabrication complexity and material limitations.

    Purpose of the Study:

    • To demonstrate strong intrinsic chirality in a simple, planar metasurface.
    • To explore substrate-induced virtual 3D asymmetry as a novel strategy for optical chirality.
    • To optimize metasurface design for enhanced circular dichroism (CD).

    Main Methods:

    • Design and simulation of a single-height planar metasurface.
    • Exploiting hybridized electric- and magnetic-dipole resonances.
    • Utilizing substrate-induced virtual 3D asymmetry.
    • Employing nonlocal mode-guided in-plane perturbation to tune transmission phases.

    Main Results:

    • Achieved strong intrinsic chirality in a planar metasurface.
    • Simulations predicted a maximum circular dichroism (CD) of 0.97 near 935 nm.
    • Fabricated devices showed pronounced CD resonances with peaks of 0.57 and 0.62 for frontside and backside illumination, respectively.
    • Validated the effectiveness of the planar metasurface strategy and substrate-induced asymmetry.

    Conclusions:

    • A simple planar metasurface strategy effectively realizes strong intrinsic chirality.
    • Substrate-induced virtual 3D asymmetry is a viable approach for optical chirality.
    • The developed metasurface shows significant potential for applications requiring high circular dichroism.