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HIV-1 gp120 exposure associates with mitochondrial and pyruvate kinase M remodeling in cardiomyocytes
Maryline Santerre1, Charles N S Allen1, Sterling P Arjona1
1FELS Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine - Temple University. Philadelphia, Pennsylvania.
Objective:
To determine whether HIV-1 gp120 impairs cardiomyocyte bioenergetics.
Design/Methods:
We exposed neonatal rat ventricular myocytes to gp120 and measured mitochondrial respiration, gene expression, and metabolites.
Results:
gp120 reduced maximal and spare respiratory capacity ( P < 0.0001), induced PTBP1 upregulation with PKM1-to-PKM2 switching, and increased lactate production.
Conclusion:
gp120 causes cardiac metabolic reprogramming and mitochondrial dysfunction. The PTBP1-PKM2 axis represents a potential therapeutic target for HIV-associated cardiovascular disease.
