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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Jul 9, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Racial Disparities in Post-transplant Outcomes for Hepatocellular Carcinoma: Systematic Review and Meta-analysis.

Muhammad Umar Nasir1, Muhammad Umer2, Abdul Wahid Rizwan2

  • 1Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.

The Journal of Surgical Research
|April 1, 2026
PubMed
Summary

Black patients with liver cancer experience worse survival after liver transplant compared to other ethnic groups. Further research is needed to understand and address these disparities in post-transplant outcomes.

Keywords:
Hepatocellular carcinomaLiverLiver cancerRaceRacialTransplant

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Area of Science:

  • Hepatobiliary Surgery
  • Transplant Immunology
  • Health Disparities Research

Background:

  • Liver transplantation is a primary treatment for hepatocellular carcinoma.
  • Significant ethnic disparities exist in post-transplant outcomes.
  • Understanding these disparities is crucial for equitable patient care.

Purpose of the Study:

  • To investigate the association between patient ethnicity and post-liver transplant outcomes.
  • To analyze survival rates across diverse racial groups undergoing liver transplantation for hepatocellular carcinoma.

Main Methods:

  • Systematic literature review following PRISMA guidelines, including studies up to April 2025.
  • Meta-analysis of overall patient and graft survival using random effects models.
  • Risk of bias and certainty of evidence assessed using Newcastle-Ottawa Scale and GRADE tool, respectively.

Main Results:

  • Twelve retrospective cohort studies involving White, Black, Asian, and Hispanic populations were analyzed.
  • Black patients demonstrated significantly poorer overall patient and graft survival post-transplant (HR=1.27).
  • Asian and Hispanic patients showed similar survival rates compared to White patients, with moderate certainty of evidence.

Conclusions:

  • Black patients with hepatocellular carcinoma face consistently worse outcomes after liver transplantation.
  • Future studies require larger, multi-ethnic cohorts and adjusted analyses to identify factors driving these ethnic disparities.