Related Experiment Video
Updated: Jun 18, 2026

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
Traumatic Brain Injury and Risk of Intracranial Meningioma : A Systematic Review and Meta-Analysis
Ahood Mahjari1, Abdullah Alyazidi1, Khaled El-Sayed1
1Department of Neurosurgery, King Khalid Hospital, Najran, Kingdom of Saudi Arabia.
Traumatic brain injury (TBI) is associated with a nearly twofold increased risk of meningioma, the most common brain tumor. However, current evidence does not confirm a causal link, necessitating further research.
Area of Science:
- Neuro-oncology
- Epidemiology
- Trauma Research
Background:
- Meningiomas are the most common primary intracranial tumors.
- The association between traumatic brain injury (TBI) and meningioma risk is not well-established.
Purpose of the Study:
- To systematically review and quantitatively synthesize observational evidence on TBI and subsequent meningioma risk.
Main Methods:
- Systematic review and meta-analysis of observational studies (PubMed, Scopus, Web of Science, Cochrane).
- Included studies compared meningioma incidence in individuals with and without TBI history.
- Risk of bias assessed using Newcastle-Ottawa Scale; random-effects models used for pooled ORs and CIs.
Main Results:
- Ten observational studies (8 for meta-analysis) were included.
- A statistically significant association between TBI and meningioma was found (OR = 1.96; 95% CI [1.31 to 2.95]).
- Moderate heterogeneity (I² = 65.6%) and potential publication bias were noted.
Conclusions:
- A statistical association exists between TBI and meningioma diagnosis.
- Current evidence does not support a clear causal relationship due to study design limitations (recall/detection bias in case-control studies).
- Large-scale prospective studies are required to clarify the etiological link.
More Related Videos
09:49Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
08:27Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
Published on: April 11, 2025
Related Concept Videos
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology
Traumatic Brain Injury l: Introduction
Increased Intracranial Pressure l: Introduction
Increased Intracranial Pressure ll: Pathophysiology