Related Experiment Video
Updated: Apr 3, 2026
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
35.5K
Hematopoietic stem cell senescence and opportunities for intervention
Aditya Barve1, Preeti Dabas1, Terri Cain1
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN.
Experimental Hematology
|April 1, 2026
Summary
Cellular senescence in hematopoietic stem cells (HSCs) is complex and impacts aging and disease. Targeting HSC senescence may restore hematopoietic function and prevent hematologic disorders.
Area of Science:
- Hematology
- Stem Cell Biology
- Aging Research
Background:
- The cellular state of senescence in hematopoietic stem cells (HSCs) is poorly understood.
- Senescence accumulation may drive age-related HSC dysfunction and increase susceptibility to hematologic disorders.
Purpose of the Study:
- To review intrinsic and extrinsic factors contributing to HSC senescence.
- To summarize strategies for targeting HSC senescence to restore hematopoietic function.
Main Methods:
- Literature review of factors influencing HSC senescence.
- Summary of molecular hallmarks and signaling pathways in HSC senescence.
- Analysis of therapeutic targets for mitigating HSC senescence.
Main Results:
- HSC senescence is influenced by genetic instability, epigenetic changes, niche alterations, and metabolic dysregulation.
- Senescence impairs HSC self-renewal, differentiation, and regenerative potential.
- Recent research identifies molecular targets for therapeutic intervention.
Conclusions:
- Understanding HSC senescence is crucial for addressing age-associated hematopoietic decline.
- Targeting senescence pathways offers potential for treating hematologic diseases and improving HSC function in aging.
Related Concept Videos
01:19Multipotency of Hematopoietic Stem Cells
4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K
01:01Regulation of Hematopoietic Stem Cells
4.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.4K
02:15Replicative Cell Senescence
3.5K
3.5K
02:15Replicative Cell Senescence
4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
01:17Stem Cell Culture
6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K
01:22iPS Cell Differentiation
3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K