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Center-Surround Processing in Psychosis.

Samantha A Montoya1, Hannah R Moser2, Rohit S Kamath2

  • 1Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|April 1, 2026
PubMed
Summary
This summary is machine-generated.

People with psychotic psychopathology show altered visual processing, specifically weaker surround suppression in the lateral occipital complex but not V1. Neural and behavioral measures did not reveal significant group differences in surround suppression.

Keywords:
Biological relativesBipolar disorderFunctional MRIMR spectroscopySchizophreniaSurround suppression

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Area of Science:

  • Neuroscience
  • Visual Perception
  • Psychopathology

Background:

  • People with psychotic psychopathology (PwPP) exhibit altered visual perception.
  • Contrast surround suppression is a visual illusion where a central pattern's contrast is reduced by a surrounding pattern.
  • PwPP typically display weaker contrast surround suppression than controls, but underlying mechanisms remain unclear.

Purpose of the Study:

  • Investigate perceptual and neural mechanisms of surround suppression in PwPP and their relatives.
  • Examine visual cortex and lateral geniculate nucleus (LGN) responses using fMRI.
  • Assess the relationship between surround suppression, GABA levels, and symptom severity.

Main Methods:

  • Assessed surround suppression in 38 controls, 44 relatives, and 64 PwPP.
  • Quantified contrast discrimination thresholds and 7 tesla fMRI responses in LGN, V1, and LOC.
  • Measured occipital GABA concentration using 7 T MR spectroscopy.

Main Results:

  • Lateral occipital complex (LOC) showed weaker surround suppression in PwPP and relatives compared to controls.
  • No significant group differences in surround suppression strength were observed in V1.
  • Behavioral measures and suppression metrics did not correlate with GABA levels or symptom severity.

Conclusions:

  • Subtle differences in visual center-surround processing exist in PwPP.
  • Discrepancies with prior research may stem from task design and attentional differences.
  • Findings highlight the complexity of visual processing alterations in psychotic psychopathology.