Consensus Recommendations for Disease- and Treatment-Related Fatigue in Patients With Advanced Prostate Cancer: A...

Area of Science:

• Oncology
• Palliative Care
• Patient Management

Background:

• Fatigue is a prevalent symptom in advanced prostate cancer (aPC), impacting patients due to disease or treatment.
• Effective management strategies are crucial for improving quality of life in aPC patients.

Purpose of the Study:

• To develop evidence-based, consensus-driven statements for managing fatigue in advanced prostate cancer patients.
• To support shared decision-making between patients and healthcare providers regarding fatigue management.

Main Methods:

• A targeted literature review identified initial fatigue management strategies.
• Expert advisors and a modified Delphi panel, including oncologists, urologists, and allied health professionals, refined these strategies.
• Consensus (≥75% agreement) was reached on 15 statements, considering effectiveness, accessibility, and feasibility.

Main Results:

• Fifteen fatigue management strategies were finalized and grouped into four categories: exercise, diet/nutrition, clinical management, and other strategies.
• Exercise strategies included endurance, strength, aerobic, and resistance training.
• Diet/nutrition focused on hydration and healthy eating; clinical management included counseling and support groups; other strategies involved acupuncture and sleep habits.

Conclusions:

• The developed statements offer practical, evidence-based guidance for managing aPC-related fatigue.
• These recommendations aim to enhance the quality of life for patients with advanced prostate cancer.
• Future research should focus on high-quality studies for fatigue management strategies in aPC, especially in evidence-limited areas.