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Published on: June 2, 2020
IMDD: A Database for Exploring Tissue-Specific Gene Expression Dynamics During Holometabolous Insects
Haoran Xu1, Jiahe Sun1, Fang Lu1
1Biological Science Research Center, Southwest University, Chongqing 400715, China.
None:
The intricate process of insect metamorphosis is governed by precise tissue-specific gene expression dynamics. To facilitate the exploration of these complex regulatory programs, we have developed the Insect Metamorphic Development Database (IMDD), an interactive platform for four key holometabolous species, including Drosophila melanogaster, Bombyx mori, Aedes aegypti and Apis mellifera, which hold significant ecological, economic, and medical importance. IMDD integrates over 1200 bulk-tissue transcriptomes and more than 1.4 million single-cell profiles, providing broad coverage of developmental stages. The platform is specifically designed to empower researchers to explore dynamic gene expression changes at both tissue and single-cell resolutions, investigate cellular heterogeneity, and trace cell-type transitions. By providing a user-friendly interface for dissecting the molecular underpinnings of insect development, IMDD serves as a critical resource for exploring the spatiotemporal gene regulatory networks that drive metamorphosis. The database is freely accessible at http://www.bioimdd.com/.
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