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Updated: Apr 3, 2026
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
SuFEx-Functionalized Pyrroles via Regioselective 1,3-Dipolar Cycloaddition of Münchnones
Jayalakshmi Achath1,2, Malu Biju1, Sreejith K Aravindakshan1,2
1Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram 695019, India.
None:
We have devised a regioselective synthesis of sulfonyl fluoride-functionalized pyrroles via the 1,3-dipolar cycloaddition of münchnones with 1-bromoethene-1-sulfonyl fluoride. The methodology was scalable and could realize the synthesis of a wide variety of functionalized pyrroles. By subjecting the sulfonyl fluoride-functionalized pyrroles to SuFEx conditions, we could generate interesting pyrrole sulfonamides and sulfonates.
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