Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

12.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
12.7K
Feedback Inhibition00:46

Feedback Inhibition

58.7K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
58.7K
Complementation Tests00:49

Complementation Tests

6.5K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.5K
Enzyme Inhibition01:30

Enzyme Inhibition

95.1K
Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
95.1K
Antimicrobial Proteins01:23

Antimicrobial Proteins

15.4K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
15.4K
Antibody Actions01:26

Antibody Actions

3.9K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Giant infiltrative myxopapillary ependymoma of filum terminale with sacral erosion: a case report and literature review.

Annals of medicine and surgery (2012)·2026
Same author

Discovery and Validation of SVEP1 and Other Novel Cardiovascular Biomarkers For Patients with Kidney Failure On Maintenance Hemodialysis.

medRxiv : the preprint server for health sciences·2026
Same author

Thrombotic Microangiopathy And Hypertensive Emergency After Cocaine Use: A Case Report.

Journal of Brown hospital medicine·2026
Same author

Metabolite correlation-based network analysis combined with machine learning techniques highlights LOX biosynthesis in Vanilla planifolia and Vanilla pompona source leaves.

Scientific reports·2026
Same author

Incidental finding of a congenital diaphragmatic hernia in a middle-aged female: a rare case report and review of the literature.

Annals of medicine and surgery (2012)·2026
Same author

Urine Microscopy: The Enduring Value of a Classic Test.

Kidney360·2025
Same journal

A 20-year-old woman with a 9-year history of shortness of breath.

Cleveland Clinic journal of medicine·2026
Same journal

A 70-year-old man with lower-extremity weakness and falls.

Cleveland Clinic journal of medicine·2026
Same journal

Treatment-refractory hypothyroidism: Don't just increase the dose.

Cleveland Clinic journal of medicine·2026
Same journal

In Reply: Beyond histologic improvement in MASH.

Cleveland Clinic journal of medicine·2026
Same journal

Comfort care: Creating a plan for hospitalized patients and their families.

Cleveland Clinic journal of medicine·2026
Same journal

Localized dead bone, a potential hint to an underlying condition.

Cleveland Clinic journal of medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.8K

Complement inhibition: A whole new world.

Nicholas Salupo1, Korey Bartolomeo2, Elias Bassil3

  • 1Ohio University Heritage College of Osteopathic Medicine, Athens, OH; Dayton Kidney, Dayton, OH.

Cleveland Clinic Journal of Medicine
|April 1, 2026
PubMed
Summary
This summary is machine-generated.

The complement system is crucial for innate and adaptive immunity. Inhibiting this system offers new treatments for inflammatory and autoimmune diseases, making it vital for medical professionals to understand these therapies.

More Related Videos

Measuring the 50% Haemolytic Complement CH50 Activity of Serum
08:26

Measuring the 50% Haemolytic Complement CH50 Activity of Serum

Published on: March 29, 2010

39.2K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.4K

Related Experiment Videos

Last Updated: Apr 3, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.8K
Measuring the 50% Haemolytic Complement CH50 Activity of Serum
08:26

Measuring the 50% Haemolytic Complement CH50 Activity of Serum

Published on: March 29, 2010

39.2K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

31.4K

Area of Science:

  • Immunology
  • Pharmacology

Background:

  • The complement system is integral to innate immunity and bridges to adaptive immunity.
  • Dysregulation of the complement system is implicated in numerous inflammatory and autoimmune conditions.

Purpose of the Study:

  • To highlight the growing importance of complement system inhibitors in treating various diseases.
  • To emphasize the need for medical professionals to be knowledgeable about these emerging therapies.

Main Methods:

  • Review of current literature on complement system function and dysregulation.
  • Analysis of the therapeutic applications and approved indications of complement inhibitors.

Main Results:

  • Complement system inhibitors have shown significant efficacy in previously untreatable diseases.
  • The range of approved indications for these drugs is expanding rapidly.

Conclusions:

  • Understanding the complement system and its inhibitors is essential for modern medical practice.
  • These therapies represent a significant advancement in managing inflammatory and autoimmune disorders.