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A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...

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Sequential Vertex-Specific Modulation of Enantiopure Metal Nanoclusters.

Yu-Jin Kong¹, Hong-Ren Li¹, Yuan Tian¹

¹College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.

Journal of the American Chemical Society

|April 1, 2026

Summary

Researchers developed a scalable synthesis for precisely controlling silver nanocluster surfaces. This method allows sequential atom addition, creating new chiral nanomaterials with tunable properties for applications like chiral sensing.

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Area of Science:

Nanotechnology
Materials Science
Supramolecular Chemistry

Background:

Controlled surface modulation of nanoclusters is crucial for nanotechnology but difficult to achieve.
Atomically precise silver nanoclusters offer tunable electronic and optical properties.

Purpose of the Study:

To develop a scalable synthesis for sequential vertex modulation in homochiral silver nanoclusters.
To investigate the geometric evolution and property changes during nanocluster growth.

Main Methods:

Scalable crystallization synthesis to generate mixed-phase cocrystallized R/S-Ag19·Ag20.
Kinetic and thermodynamic control to sequentially add silver atoms to nanocluster facets.
Characterization of nanocluster structures (Ag19, Ag20, Ag21) and their electronic properties.

Main Results:

Achieved sequential vertex modulation in homochiral silver nanoclusters (Ag19 to Ag21).
Demonstrated geometric evolution analogous to borane cluster transformations (arachno → nido → closo).
Induced luminescence in Ag21 nanoclusters and enabled quantitative chiral sensing of amino acids.

Conclusions:

The developed synthesis provides a framework for controlled nanocluster surface modulation.
Sequential vertex addition fine-tunes nanocluster properties, leading to functional chiral materials.
R/S-Ag21 nanoclusters show promise for sensitive chiral sensing applications.