Related Experiment Video

Updated: Apr 3, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K

Frailty Modifies the Predictive Capacity of the Triglyceride-Glucose Index for Coronary Heart Disease

Peng Gao1, Chunlei Li1, Ran Liu1

  • 1Department of Cardiology, Beijing Luhe Hospital, Affiliated to Capital Medical University.

International Heart Journal
|April 1, 2026
PubMed

Insights

Frailty significantly impacts the triglyceride-glucose (TyG) index

Area of Science:

  • Cardiology
  • Gerontology
  • Metabolic Syndrome

Background:

  • Coronary heart disease (CHD) is a leading cause of mortality globally.
  • Frail populations are particularly vulnerable to CHD.
  • The triglyceride-glucose (TyG) index is a potential biomarker for cardiovascular risk.

Purpose of the Study:

  • To investigate the influence of frailty on the predictive capacity of the TyG index for CHD.
  • To assess the relationship between TyG index levels and CHD risk in both frail and non-frail individuals.

Main Methods:

  • Analysis of data from 8,080 participants.
  • Utilized the triglyceride-glucose (TyG) Index (high ≥ 8.697) and Frailty Index (frail ≥ 0.21).
  • Employed logistic regression and restricted cubic spline analyses to examine TyG-CHD associations.

Main Results:

  • In non-frail individuals, the TyG index independently predicted CHD with a near-linear relationship (OR = 1.89).
  • In frail individuals, the TyG index lost its independent predictive power and exhibited a U-shaped relationship with CHD.
  • Frailty significantly moderated the association between the TyG index and CHD (Pinteraction = 0.036).

Conclusions:

  • Frailty substantially alters the predictive value of the TyG index for coronary heart disease.
  • The TyG index is a reliable CHD predictor in non-frail individuals but less so in frail populations.
  • Incorporating frailty assessment is crucial for accurate CHD risk stratification using the TyG index.

Keywords:
Cardiovascular risk stratificationInsulin resistanceMetabolic markersNational Health SurveyPopulation-based study

More Related Videos

Frailty Assessment in an Aging Mouse Model06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

866
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.5K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.6K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
583
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
857
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
843
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
989
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
573