Errata: Aspirin and Celecoxib Regulate Notch1/Hes1 Pathway to Prevent Pressure Overload-Induced Myocardial...

Area of Science:

• Cardiovascular Biology
• Molecular Medicine
• Pharmacology

Background:

• Pressure overload leads to myocardial hypertrophy, a significant risk factor for heart failure.
• The Notch1/Hes1 signaling pathway is implicated in cardiac remodeling.
• Understanding molecular regulators is crucial for therapeutic development.

Purpose of the Study:

• To investigate the effects of aspirin and celecoxib on the Notch1/Hes1 pathway.
• To determine the role of this pathway in preventing pressure overload-induced myocardial hypertrophy.

Main Methods:

• Utilized a mouse model of pressure overload.
• Administered aspirin and celecoxib.
• Assessed cardiac hypertrophy markers and Notch1/Hes1 pathway activation via molecular and histological analyses.

Main Results:

• Aspirin and celecoxib treatment attenuated cardiac hypertrophy.
• Both drugs significantly inhibited the activation of the Notch1/Hes1 pathway in response to pressure overload.
• Downstream targets of Hes1 were modulated by the treatments.

Conclusions:

• Aspirin and celecoxib demonstrate cardioprotective effects against pressure overload.
• Regulation of the Notch1/Hes1 pathway is a key mechanism for their beneficial actions.
• Targeting this pathway may offer a therapeutic strategy for heart hypertrophy.