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Aloe-emodin microemulsion gel for diabetic wounds: optimizing surfactant-polymer synergy for effective wound
Pankaj Popli1, Sakshi Gaur1, Sushma Devi1
1Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Aim:
The present study aimed to develop and optimize an Aloe-emodin-loaded microemulsion gel (AMEG) to improve topical delivery, bioavailability, and therapeutic efficacy for diabetic wound healing.
Materials And Methods:
AMEG was formulated using a D-optimal mixture design, employing Capryol 90 as the oil phase, Labrasol and Tween 80 as surfactants, and Transcutol P as the co-surfactant. The optimized microemulsion was incorporated into a konjac glucomannan (KGM) gel matrix to enhance skin adherence and wound-healing potential. The formulation was characterized for droplet size, clarity, in vitro drug release, and ex vivo skin permeation. In vivo wound-healing efficacy was evaluated in diabetic rat models, along with biochemical and histopathological assessments.
Results:
The optimized AMEG exhibited a nanoscale droplet size of ~27.17 ± 2.65 nm with excellent clarity and stability. Sustained in vitro drug release (~45.8 ± 1.66%) and enhanced transdermal penetration (~39.5 ± 1.96%) were observed. In vivo studies demonstrated significantly accelerated wound closure, modulation of inflammatory and oxidative stress markers, and improved tissue regeneration. Histopathological evaluation confirmed complete re-epithelialization and well-organized collagen deposition.
Conclusion:
AMEG effectively overcomes the solubility and bioavailability limitations of Aloe-emodin, offering a promising topical therapeutic strategy for diabetic wound management through enhanced penetration, controlled release, and synergistic healing effects.
