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Updated: Apr 3, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
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Recurrence Rates for Mandibular Fibrosarcoma Associated With Mandibular Canal Invasion Following Mandibulectomy

Carley P Johnson1, Josephine A Dornbusch2, Owen T Skinner2

  • 1Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.

Veterinary and Comparative Oncology
|April 2, 2026
PubMed
Summary
This summary is machine-generated.

Local recurrence of oral fibrosarcoma in dogs is reduced when mandibular canal invasion is absent. This study highlights the importance of surgical margins for long-term control of this invasive canine tumor.

Keywords:
mandibular canalmandibular fibrosarcomamandibulectomyrecurrence

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Area of Science:

  • Veterinary Oncology
  • Surgical Oncology
  • Canine Cancer Research

Background:

  • Oral fibrosarcoma is a highly invasive tumor in dogs with significant local recurrence rates after surgery.
  • Optimal surgical margins for complete tumor removal, especially with mandibular canal involvement, remain unclear.
  • Mandibular fibrosarcoma recurrence impacts long-term prognosis and quality of life in affected dogs.

Purpose of the Study:

  • To evaluate the recurrence rate of mandibular fibrosarcoma in dogs following mandibulectomy.
  • To determine the association between mandibular canal invasion and local recurrence after surgery.
  • To identify factors influencing long-term local control of canine oral fibrosarcoma.

Main Methods:

  • Retrospective review of medical records from 49 dogs undergoing mandibulectomy for fibrosarcoma across 9 veterinary centers (2005-2023).
  • Data collected included tumor size, surgical procedure, margin status, and long-term outcomes.
  • Statistical analysis (Fisher's exact, Mann-Whitney U, multivariable logistic regression) was used to assess recurrence predictors.

Main Results:

  • Local recurrence was observed in 8 out of 49 dogs, with 5 of these having mandibular canal invasion.
  • Absence of mandibular canal invasion was significantly associated with reduced odds of local recurrence (OR 0.06, P=0.036) after adjusting for surgical factors.
  • No single variable individually predicted local recurrence, emphasizing the need for multivariable analysis.

Conclusions:

  • The absence of mandibular canal invasion is a key factor in reducing local recurrence of mandibular fibrosarcoma in dogs.
  • Further research is warranted to define optimal surgical margins for achieving long-term local control in these cases.
  • Accurate assessment of tumor invasion, particularly into the mandibular canal, is crucial for surgical planning and prognosis.