Treatment Response Phenotyping Informed by Patient Physiologic Characteristics Could Drive Precision Critical Care...

Andre L Holder¹, Gwénolé Abgrall¹, Ran Xiao¹+6

• ¹Division of Pulmonary, Critical Care, Allergy and Sleep Medicine (A. L. H.), Department of Medicine, Emory University School of Medicine, the Nell Hodgson Woodruff School of Nursing (R. X.), Emory University, Atlanta, GA; the Division of Cardiac Surgery (J. K.), Beth Israel Deaconess Medical Center, Boston, MA; the Department of Health Policy and Management (I. D.-M.), Milken Institute School of Public Health, George Washington University, Washington, DC; the Division of Pulmonary, Critical Care, Allergy and Sleep Medicine (A. Z.), Department of Medicine, the Cardiovascular Research Institute (A. Z.), University of California, San Francisco, San Francisco, CA; the AP-HP (G. A.), Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, DMU 4 CORREVE, Inserm UMR S_999, FHU SEPSIS, CARMAS, Université Paris-Saclay, Le Kremlin-Bicêtre; the Service de Médecine Intensive Réanimation (G. A.), Centre Hospitalier Universitaire Grenoble Alpes, La Tronche, France; the Department of Cardiology (S. N.), Alfred Hospital, the Department of Cardiology (S. N.), Cabrini Hospital, the Monash-Alfred-Baker Centre for Cardiovascular Research (S. N.), Monash University, Melbourne, VIC, Australia; the Department of Critical Care Medicine (A. Z.), University of Calgary and Alberta Health Services, Calgary; the Interdepartmental Division of Critical Care Medicine (E. C. G.), and the Department of Physiology (E. C. G.), University of Toronto, Toronto, ON, Canada.