Related Experiment Video
Updated: Apr 8, 2026
09:04
Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
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Top 100 most-cited articles on NLRP3 (2000-2024): a retrospective analysis.
Ke-Qian Chen1, Hai-Bo Lei1, Mei-Ling Huang2
1Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, China.
Frontiers in Immunology
|April 2, 2026
Summary
This study analyzed top NLRP3 inflammasome articles, revealing key researchers and institutions. Future research will focus on therapeutic applications and non-immune cell functions of NLRP3.
Area of Science:
- Immunology and Molecular Biology
- Biomedical Research
Background:
- The NLRP3 inflammasome is a critical component of innate immunity, implicated in numerous inflammatory diseases.
- Understanding research trends and key players in NLRP3 inflammasome studies is crucial for advancing the field.
Purpose of the Study:
- To identify and analyze the top 100 most-cited articles in NLRP3 research.
- To uncover research trends, key contributors, and collaborative networks in NLRP3 inflammasome studies.
- To provide insights into the development and future directions of NLRP3 inflammasome research.
Main Methods:
- A comprehensive literature search was performed using Web of Science and PubMed (2000-2024).
- Articles were screened and ranked by citation frequency to select the top 100.
- Detailed bibliometric analysis of citations, authors, countries, institutions, journals, and funding sources was conducted.
Main Results:
- The top 100 articles involved 811 authors, 25 countries, and 224 institutions.
- E. Latz, the USA, University of Massachusetts, and Nature journal were identified as leading contributors in terms of publications and citations.
- The research spanned 19 fields and involved 218 funding sources.
Conclusions:
- NLRP3 inflammasome research is growing and interdisciplinary, with significant contributions from the USA, leading institutions, and high-impact journals.
- Future research directions include translational applications, development of NLRP3 inhibitors/activators, and exploring NLRP3 functions in non-immune cells.
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