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Localized Temperature Monitoring in Mouse Brain during Light Delivery via a Non-Planar Tapered Fiber-Integrated µRTD

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Summary

This study introduces a novel neural interface that combines light delivery and precise brain temperature monitoring. The integrated micro-sensor enhances safety and understanding of optical neuromodulation techniques.

Keywords:
multifunctional neural interfacesoptogeneticstapered optical fiberstemperature monitoringtwo‐photon polymerization

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Precise monitoring of local brain temperature is crucial for understanding neural processes.
  • Optical neuromodulation techniques require careful management of thermal side effects.
  • Existing multimodal probes often have spatial mismatches and larger footprints.

Purpose of the Study:

  • To develop a multifunctional neural interface integrating thermal sensing with optical light delivery.
  • To achieve co-localized sensing and stimulation with a minimal footprint.
  • To improve the safety and interpretability of optical neurotechnologies.

Main Methods:

  • Integration of a microscale resistance temperature detector (µRTD) onto a tapered optical fiber (TF).
  • Fabrication of the µRTD using a two-photon polymerization (TPP) process.
  • Demonstration of thermal sensing during optogenetic stimulation/inhibition protocols.

Main Results:

  • The µRTD demonstrated high thermal sensitivity (<0.1°C) with low self-heating.
  • Subtle temperature changes induced by optogenetic protocols were resolved.
  • Significant thermal accumulation was observed only under prolonged, high-intensity illumination.

Conclusions:

  • The novel interface enables co-localized optical delivery and thermal sensing, reducing spatial mismatch and implant size.
  • The TPP approach offers modularity for integrating additional functionalities.
  • This technology provides a powerful tool for studying thermally mediated neural processes and enhancing optical neurotechnology safety.