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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Apr 3, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Spitz Melanocytoma With a Novel CPEB2::MAP3K2 Rearrangement: A Case Report.

John L McAfee¹, Claudia M Ricotti^1,2, Shira Ronen¹

¹Department of Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Journal of Cutaneous Pathology

|April 2, 2026

Summary

A rare Spitz tumor in an 18-year-old revealed a novel CPEB2::MAP3K2 gene fusion, previously unreported in human tumors. Further monitoring is needed to understand this unique melanocytic lesion.

Area of Science:

Oncology
Genetics
Dermatopathology

Background:

Spitz tumors often involve gene fusions in receptor tyrosine kinase or MAPK pathways.
Understanding genetic alterations is crucial for diagnosing and managing melanocytic neoplasms.

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