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Identification of the Novel HLA-B*15:752 Allele by Next-Generation Sequencing

Bide Duan1, Jin Li2, Kun Dong1

  • 1Department of Obstetrics, Zibo Central Hospital, Zibo, Shandong Province, China.

HLA
|April 2, 2026
PubMed

Abstract:

HLA-B*15:752 differs from HLA-B*15:01:01:01 by a C > A substitution at cDNA position 194.

Keywords:
HLA‐B*15:752HLA‐Bnext‐generation sequencingnovel allele

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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