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Advances of Green-Synthesized Nanoparticles for Biomedical Applications
Md Hosne Mobarak1, Md Zobair Al Mahmud1, Amran Hossain1
1Department of Mechanical Engineering, IUBAT-International University of Business Agriculture and Technology, Dhaka, Bangladesh, iubat.edu.
Biomed Research International
|April 2, 2026
Summary
Plant-derived metallic nanoparticles offer a safer, biocompatible alternative for biomedical applications. This review highlights their potential in medicine, from fighting infections to drug delivery, while noting challenges for widespread use.
Area of Science:
- Biomedical Nanotechnology
- Materials Science
- Plant-based Synthesis
Background:
- Plant-mediated metallic nanoparticle synthesis offers reduced toxicity and improved biocompatibility.
- Phytochemicals act as reducing, stabilizing, and capping agents, enabling controlled nanoparticle production.
- Nanoparticle properties like size, shape, and surface charge influence biological performance.
Purpose of the Study:
- To review recent advancements in plant-derived nanoparticle synthesis and characterization.
- To summarize their biomedical applications, including antimicrobial, anticancer, and drug delivery uses.
- To identify knowledge gaps and challenges for clinical translation.
Main Methods:
- Semisystematic literature review of studies from 2015-2024.
- Analysis of over 120 studies on plant-derived nanoparticle synthesis and applications.
- Inclusion of spectroscopic, microscopic, and surface analytical methods for characterization.
Main Results:
- Plant-derived nanoparticles demonstrate significant potential in antimicrobial therapy, anticancer applications, and wound healing.
- Controlled production via plant extracts allows for tailored physicochemical properties.
- Developments in analytical techniques enhance understanding of structure-activity relationships.
Conclusions:
- Plant-derived nanoparticles show promising biomedical potential, particularly in drug delivery and therapeutics.
- Standardization, reproducibility, and scalability remain key challenges for clinical translation.
- Further research is needed to bridge the gap between laboratory findings and clinical application.
