Related Experiment Video
Updated: Apr 3, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
A Cardio-Obstetric Breakthrough Beyond Routine Pregnancy Care: Unmasking Hodgkin's Lymphoma
Afifa Sabahat Baig1, Sameen Jawed1, Sumiya Gurmani1
1National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Background:
Multidisciplinary care during pregnancy is essential to ensure safe maternal and fetal outcomes, particularly when managing serious conditions such as Hodgkin's lymphoma.
Case Summary:
A 24-year-old pregnant woman presented with dyspnea and neck swelling. Echocardiography revealed cardiac tamponade, managed by pericardiocentesis. Histopathology confirmed Hodgkin's lymphoma. Multidisciplinary care and third-trimester ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy led to clinical recovery and delivery of a healthy newborn. Postpartum positron emission tomography/computed tomography scan demonstrated a significant disease regression.
Discussion:
Cardiac tamponade as an initial manifestation of Hodgkin's lymphoma is rare. This case underscores the need to evaluate unexplained pericardial effusion in pregnancy for possible malignancy and highlights that early diagnosis, drainage, and timely chemotherapy are key to prevent instability and achieving recovery.
Take-Home Messages:
Unexplained pericardial effusion in pregnancy should prompt evaluation for underlying malignancy including lymphomas.
Related Concept Videos
Mitral Valve Prolapse III: Nursing Management
Cytomegalovirus Disease
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Teratogenicity
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

