Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

2.2K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.2K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comment on "Blink-induced epileptic negative myoclonus in CHD2-related epilepsy: A novel seizure semiology linked to visual transient hyperexcitability".

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

The emerging roles of cerebral pericytes in brain metastasis.

Neuro-oncology·2026
Same author

Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling.

Science advances·2026
Same author

EEG and surface-electromyography correlate of tonic seizures in supplementary sensorimotor area epilepsy.

Epileptic disorders : international epilepsy journal with videotape·2026
Same author

Neurourology & overactive bladder: first International Functional and Reconstructive Urology Update August 29, 2024-Denver, Colorado.

Therapeutic advances in urology·2025
Same author

Drinking artifact on scalp-EEG.

Epileptic disorders : international epilepsy journal with videotape·2025
Same journal

Surface EEG to Identify Cognitive Motor Dissociation After Acute Brain Injury.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

The Physics and Physiology of Electrical Stimulation of the Brain.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Neurophysiology in Postanoxic Encephalopathy: Pathophysiology, Prognosis, and Treatment.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

A Review on the Functional Connectivity of the Human Opercular Cortex.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Surgical Aspects of Opercular Epilepsies.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
Same journal

Cost-Effectiveness of EEG Monitoring in Hypoxic-Ischemic Brain Injury After Cardiac Arrest.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
08:43

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

Published on: July 21, 2015

26.5K

Generalized Periodic Discharges: Nonconvulsive Status Epilepticus or Diffuse Encephalopathy-A Case Comparison.

Chanawee Hirunpattarasilp1,2, Joshua Edmondson1,3, Daniel Wood1,4

  • 1Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, U.S.A.

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|April 2, 2026
PubMed
Summary
This summary is machine-generated.

Nonconvulsive status epilepticus (NCSE) presents differently in comatose versus non-comatose patients. Coma in NCSE may not stem from epileptiform discharges, unlike the responsive state in non-comatose NCSE.

Keywords:
Generalized periodic dischargesNonconvulsive status epilepticusToxic–metabolic encephalopathy

More Related Videos

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

18.3K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.9K

Related Experiment Videos

Last Updated: Apr 3, 2026

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
08:43

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

Published on: July 21, 2015

26.5K
Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

18.3K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.9K

Area of Science:

  • Neurology
  • Clinical Neurophysiology

Background:

  • Nonconvulsive status epilepticus (NCSE) is defined by persistent epileptiform discharges on electroencephalogram (EEG) meeting Salzburg criteria.
  • NCSE manifests with varying levels of consciousness, including coma and dialepsis (unresponsiveness with amnesia).

Purpose of the Study:

  • To describe a case of NCSE with coma induced by ceftriaxone neurotoxicity.
  • To compare the electroclinical features of NCSE with coma to NCSE without coma in a patient with chronic epilepsy.

Main Methods:

  • Case report analysis.
  • EEG monitoring and electroclinical correlation.

Main Results:

  • Generalized periodic discharges (GPDs) in NCSE with coma might be epiphenomenal, not directly causing coma.
  • The dialeptic state in NCSE without coma is a direct result of epileptiform discharges, requiring treatment.

Conclusions:

  • NCSE with coma and NCSE without coma have distinct underlying mechanisms and clinical presentations.
  • Ceftriaxone can induce NCSE with coma, highlighting the importance of neurotoxicity assessment in critically ill patients.