Related Experiment Video
Updated: Apr 3, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
THEMIS: new insights into its evolution, structure, and function
Avik Dutta1, L Aravind2, Seeyoung Choi1
1Section on Hematopoiesis and Lymphocyte Biology, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
None:
THEMIS (thymocyte-expressed molecule involved in selection) is the founding member of a family of metazoan proteins distinguished by the presence of a novel structural element designated the cysteine-containing all-beta-in-THEMIS (CABIT) module. Several studies have confirmed a critical role for THEMIS in T cell antigen receptor (TCR) signaling during T cell development, and more recent work has shown an important role for THEMIS in peripheral T cells. However, the molecular function of THEMIS in the TCR signaling pathway has long remained controversial due to conflicting experimental results. In this review article, we summarize recent data that provide new insights into the structure, evolution, and broader roles of the CABIT module, as well as clarify the molecular mechanism by which THEMIS influences TCR and cytokine receptor signaling in developing and mature T cells.
Related Concept Videos
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
The Phragmoplast
The...
The Phragmoplast
Introduction to the Integumentary System
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Diencephalon: Hypothalamus and Coordination
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
Structures of the Endocrine System

