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Updated: Apr 3, 2026

Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
Published on: July 7, 2022
Reprogramming aging astrocytes in Alzheimer's disease
Maria Alfonso-Triguero1, Amaia M Arranz2
1Achucarro Basque Center for Neuroscience, Leioa, Spain; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.
Abstract:
Alzheimer's disease typically unfolds within an aging brain, where astrocytic transcriptional programs are extensively remodeled. A recent study by Choi and colleagues shows that reinstating an aging-dependent Sox9-MEGF10 axis restores amyloid clearance and preserves cognition in mouse models. These findings suggest that astrocyte dysfunction reflects destabilized, yet recoverable, homeostatic programs rather than irreversible degeneration.
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