Related Experiment Video
Updated: Apr 3, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
Published on: March 17, 2023
Shaping cell therapy manufacturing with metabolic understanding and control
Constança M Costa1, Ana Paula Terrasso1, Marta H G Costa1
1iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras 2780-901, Portugal; Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, Oeiras 2780-157, Portugal.
Abstract:
The clinical efficacy of cell therapy products is intrinsically related to their state of differentiation and maturity. However, current approaches to target cell phenotype and potency lack efficacy, scalability, and cost-effectiveness. Metabolism is a key driver of cell fate, a characteristic that can be explored to design bioprocesses yielding functional cell therapy products. Here, we review recent studies focused on exploring metabolic shifts to improve cell potency and discuss how these strategies can contribute to accelerating bioprocess development and benefit from their translation into scalable, tightly controlled, and affordable manufacturing workflows.
Related Concept Videos
Bioreactor Controls-III
Upstream Processing

