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Development of Proteinuria in Patient With Solitary Kidney on Rosuvastatin
Joy A Stouffer1, Barinder S Hansra2
1Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background:
High-dose rosuvastatin (40 mg) has been associated with transient proteinuria, particularly in patients with severe chronic kidney disease.
Case Summary:
We report a 59-year-old woman with a solitary kidney who developed proteinuria while on rosuvastatin 40 mg daily. The reduction of the dose to 10 mg daily led to complete resolution of proteinuria.
Discussion:
The Food and Drug Administration recommendations advise a dose reduction of rosuvastatin to 10 mg in patients with severe chronic kidney disease, but no guidance exists for individuals with a solitary kidney and preserved renal function. This case suggests that these patients may be at risk of rosuvastatin-associated proteinuria and could benefit from lower doses.
Take-Home Messages:
Clinicians should use caution when prescribing high-dose rosuvastatin in patients with a solitary kidney. Further study is warranted to clarify whether solitary kidney status independently increases the risk of proteinuria.
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