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RANKL-inducible Arl8b effector RUFY4 drives HOPS-mediated lysosomal maturation and trafficking in osteoclasts

Kshitiz Walia1,2, Gaurav Kumar1, Subhash B Arya1

  • 1Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh, India.

Molecular Biology of the Cell
|April 2, 2026
PubMed
Summary

The small GTPase Arl8b and its effector RUFY4 are crucial for secretory lysosome positioning and maturation in osteoclasts. This pathway is essential for cathepsin K processing and effective bone resorption during remodeling.

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