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Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
Published on: January 26, 2024
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Influence of Tumor-Draining Lymph Nodes on Immunotherapy: Lymphadenectomy May Have Its Limits
1Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Abstract:
In this issue of CCR Translations, it is explored whether removing fewer than usual tumor-draining lymph nodes (LN) at surgical resection might offer better outcomes in patients subsequently receiving immunotherapy. These LNs likely host coordinated adaptive immune responses and may be a key reason why neoadjuvant immunotherapy is exhibiting remarkable clinical success. See related article by Long et al., p. 2467.
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