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Inducement and Evaluation of a Murine Model of Experimental Myopia

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Karen Lahav-Yacouel^1,2, Daniel Tilia^1,2, Darrin Falk^1,2

¹nthalmic Pty Ltd, Sydney, New South Wales, Australia.

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|April 2, 2026

Summary

P.A.U.S.E. spectacle lenses demonstrated superior visual performance in the treatment zone compared to DIMS lenses. Lens T2 offered better overall visual performance than DIMS, while DIMS outperformed T1.

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Area of Science:

Ophthalmology
Optometry
Vision Science

Background:

Spectacle lenses play a crucial role in vision correction and myopia management.
Defocus Incorporated Multiple Segments (DIMS) lenses are a common control for evaluating novel lens designs.
Assessing visual performance (VP) is key to understanding lens efficacy.

Purpose of the Study:

To compare the visual performance (VP) of P.A.U.S.E. spectacle lenses against Defocus Incorporated Multiple Segments (DIMS) lenses.
Evaluate objective and subjective visual parameters across different lens designs.

Main Methods:

A randomized, single-masked study involving 48 participants (aged 18-41 years).
Participants wore five P.A.U.S.E. lens designs (T1, T2, T4, T5, T6) and DIMS lenses.
Visual acuity (VA) was measured (full-lens and treatment zone), alongside subjective ratings for near vision, night vision, and overall satisfaction.

Main Results:

P.A.U.S.E. lenses (T2, T4, T5) showed significantly better full-lens binocular high-contrast visual acuity (HCVA) at 40 cm compared to DIMS.
Four P.A.U.S.E. lenses (T2, T4, T5, T6) demonstrated superior HCVA, near vision clarity, and ease-of-reading through the treatment zone.
Lens T2 received higher ratings for night vision and overall vision satisfaction than DIMS, while DIMS outperformed T1 in vision clarity.

Conclusions:

Most P.A.U.S.E. spectacle lenses provided enhanced visual performance through their treatment zones compared to DIMS.
Lens T2 exhibited better overall visual performance than DIMS, whereas DIMS showed better performance than T1.