Related Experiment Video
Updated: Apr 4, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
Assessing the Influence of Shift Timing on Mortality Rates in <32-Week Preterm Infants.
Mustafa Senol Akin1, Ufuk Cakir1
1Division of Neonatology, Department of Pediatrics, Ministry of Health Ankara Bilkent City Hospital, Çankaya, Ankara, Turkey.
Neonatal intensive care unit (NICU) staffing changes during off-duty hours did not impact infant mortality rates. Premature infant outcomes remained consistent despite fewer physicians working overnight shifts.
Area of Science:
- Neonatology
- Pediatric Critical Care
- Healthcare Management
Background:
- Continuous patient care quality is vital in neonatal intensive care units (NICUs).
- Staffing levels and intervention timing can fluctuate with working hours, potentially influencing clinical outcomes.
- The impact of on-duty versus off-duty hours on neonatal mortality requires further investigation.
Purpose of the Study:
- To examine clinical data of deceased premature infants during on- and off-duty hours.
- To assess the frequency of neonatal mortality in relation to working hours.
- To determine if reduced physician presence during off-duty hours affects mortality and morbidity in premature infants.
Main Methods:
- Retrospective cohort analysis at a single institution.
- Inclusion of deceased infants born at or before 32 weeks' gestation (WG).
- Classification of patient deaths based on on-duty/off-duty periods and three 8-hour shifts.
Main Results:
- 256 deceased premature infants were analyzed; 66 (25.8%) during on-duty and 190 (74.2%) during off-duty hours.
- Off-duty periods were longer, yet mortality rates per unit time were comparable between on- and off-duty groups.
- Physician numbers decreased 4.5-fold during off-duty hours, but infant mortality and morbidity remained unchanged.
Conclusions:
- Reduced physician staffing during off-duty hours in the NICU did not correlate with increased mortality or morbidity for premature infants (≤32 WG).
- The study suggests that established protocols and team structures may mitigate risks associated with reduced on-site physician presence during off-duty periods.
- Further research could explore specific factors contributing to consistent outcomes across different staffing levels.
Related Concept Videos
Regression Toward the Mean
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Development of Human Microbiota

