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Updated: Apr 4, 2026

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Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
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Eustachian Tube Obliteration for Temporal Bone Cerebrospinal Fluid Leaks
Manick S Saran1, Aparna Govindan1, Fred Telischi1
1Department of Otolaryngology, University of Miami, Miami, USA.
Otolaryngologic Clinics of North America
|April 2, 2026
Summary
Temporal bone cerebrospinal fluid (CSF) leaks require high suspicion and beta-2 transferrin testing. Eustachian tube obliteration (ETO) via transmastoid approach is effective for refractory CSF leaks.
Area of Science:
- Neurosurgery
- Otolaryngology
- Neurology
Background:
- Temporal bone cerebrospinal fluid (CSF) leaks often manifest as unilateral rhinorrhea or otorrhea.
- Increased intracranial pressure can exacerbate CSF leaks.
- Beta-2 transferrin assay is the gold standard for confirming CSF otorrhea/nasal secretions.
Purpose of the Study:
- To highlight the role of Eustachian tube obliteration (ETO) in managing CSF leaks.
- To discuss the transmastoid approach as a key technique for ETO.
Main Methods:
- Review of clinical presentation and diagnostic standards for temporal bone CSF leaks.
- Description of Eustachian tube obliteration (ETO) as an adjunctive therapy.
- Emphasis on the transmastoid surgical approach for ETO.
Main Results:
- ETO is a valuable strategy for high-flow or refractory CSF leaks.
- The transmastoid approach is a historically significant and successful method for ETO.
Conclusions:
- Early suspicion and accurate diagnosis are crucial for managing temporal bone CSF leaks.
- ETO, particularly via the transmastoid route, offers an effective solution for persistent CSF leaks.
- Conservative therapies may fail, necessitating surgical intervention like ETO.
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