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Related Experiment Video

Updated: Apr 4, 2026

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
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Regrowth Patterns in Glioblastoma-Survival and Predictors.

Jonas A Feldheim1,2, Jana Grieger1, Teresa Schmidt1,3,4

  • 1Division of Clinical Neuro-Oncology, Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Cancer Medicine
|April 2, 2026
PubMed
Summary

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Temporal Muscle Thickness as a Prognostic Marker in a Real-Life Cohort of Newly Diagnosed MGMT Promoter Methylated Glioblastoma: A Multicentric Imaging Analysis.

Cancer medicine·2025

Glioblastoma recurrence patterns significantly impact patient survival. Tumor Treating Fields (TTFields) therapy may prolong progression-free survival and influence recurrence patterns, suggesting improved local control.

Area of Science:

  • Neuro-oncology
  • Medical Physics
  • Radiology

Background:

  • Glioblastomas (GBM) exhibit diverse recurrence patterns, including local, multifocal, and multicentric. The clinical implications and influencing factors of these patterns remain poorly understood.
  • Understanding GBM recurrence heterogeneity is crucial for predicting patient outcomes and optimizing treatment strategies.

Purpose of the Study:

  • To investigate whether detailed analysis of GBM recurrence patterns can identify distinct patient subgroups.
  • To determine if specific relapse patterns correlate with differences in patient survival.
  • To identify potential predictors for distinct GBM regrowth patterns.

Main Methods:

  • Retrospective analysis of demographic, tumor, and patient characteristics from 251 GBM patients treated at two institutions.
Keywords:
TTFieldsdistantlocalmulticentricmultifocalprogressionrecurrence

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  • Characterization of recurrence patterns using Magnetic Resonance Imaging (MRI) data.
  • Statistical correlation of recurrence patterns with overall survival (OS) and progression-free survival (PFS).

    • Main Results:

    • Distinct differences in overall and progression-free survival were observed between multicentric and multifocal GBM recurrences.
    • Specific relapse patterns, such as unifocal local and multicentric recurrences, were significantly associated with patient survival outcomes, independent of other prognostic factors.
    • Tumor Treating Fields (TTFields) therapy was linked to prolonged PFS (7.2 vs. 4.8 months) and predicted a higher frequency of non-local recurrence patterns (OR 0.16).
    • TTFields also predicted a longer time to local recurrence after subtotal tumor resection (mPFS 11.1 vs. 5.2 months), indicating improved local control.

    Conclusions:

    • Glioblastoma recurrence patterns are associated with distinct survival outcomes, suggesting different underlying biological mechanisms.
    • Tumor Treating Fields (TTFields) therapy demonstrates potential in prolonging progression-free survival and influencing recurrence patterns, potentially by enhancing local tumor control.