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Comparative Sensory Evaluation of Pediatric Liquid Omeprazole Formulations Available in the UK

Sejal R Ranmal1, Elisa Alessandrini2, Catherine Tuleu2

  • 1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK. sejal.ranmal@ucl.ac.uk.

Clinical Drug Investigation
|April 2, 2026
PubMed

Insights

Compounded omeprazole preparations are less palatable than licensed versions, with significant taste and aftertaste aversions. Developing better-tasting pediatric formulations is crucial for patient acceptance.

Area of Science:

  • Pharmacology
  • Sensory Science
  • Pediatric Medicine

Background:

  • Omeprazole is a key treatment for pediatric acid-related disorders.
  • Licensed liquid omeprazole formulations have variable global availability.
  • Compounded preparations are often used, with inconsistent sensory profiles.

Purpose of the Study:

  • To evaluate the palatability of different omeprazole liquid formulations.
  • To compare sensory characteristics of compounded versus licensed preparations.
  • To inform the development of acceptable pediatric formulations.

Main Methods:

  • Randomized, single-blind sensory evaluation study.
  • 30 adult volunteers assessed six UK omeprazole liquid formulations.
  • Visual analog and hedonic scales measured taste, aftertaste, smell, mouthfeel, and overall acceptability.

Main Results:

  • Compounded sodium bicarbonate suspension showed significantly higher taste and aftertaste aversiveness.
  • A licensed menthol-flavored oral solution had the lowest taste aversiveness and highest acceptability.
  • Other licensed formulations were generally mildly to moderately aversive.

Conclusions:

  • Significant sensory differences exist between compounded and licensed omeprazole liquids.
  • Palatability is a critical factor for pediatric formulation acceptance.
  • Development of palatable, age-appropriate formulations is essential.
Abstract

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