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DNA methylation signatures of treatment response in medication-overuse headache

Katarzyna Malgorzata Kwiatkowska1, Valentina Favoni2, Francesca Ferraresi3

  • 1Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126, Bologna, Italy. katarzyn.kwiatkowsk2@unibo.it.

The Journal of Headache and Pain
|April 3, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
AnalgesicsBiomarkersChronic headacheDNA methylationDetoxEpigenetic signatureMedication overuse headacheMigraineTreatment responseWithdrawal treatment

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Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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