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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
HPV-related Vulvar Disease
Sumeetha Swaminathan1, Jessica Forman2, Mary Gail Mercurio2
1School of Medicine and Dentistry, University of Rochester, Rochester, New York.
Abstract:
Human papillomaviruses (HPV) are the most common cause of sexually transmitted infections worldwide and can play a role in vulvar disease. This review provides a clinically relevant summary of our current understanding of the virology, epidemiology, and pathogenesis of HPV along with diagnosis and management strategies of condyloma acuminata, vulvar intraepithelial neoplasia (VIN), and invasive squamous cell carcinoma. Formal screening and management guidelines for vulvar disease, especially cancer, remain limited, highlighting the need for more robust evidence and consensus. Early recognition, appropriate intervention, integrating close follow-up, and prevention strategies (ie, vaccination) can greatly impact the burden of HPV-associated vulvar diseases.
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