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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

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Bioactive Peptides: Production Strategies, Biological Activities, and Emerging Therapeutic Applications.

Jasvinder Saini¹, Smita Narwal¹, Jagdeep Singh¹

¹Department of Pharmacy, Global Research Institute of Pharmacy, Radaur, 135133, Yamuna Nagar, Haryana, India.

Protein and Peptide Letters

|April 3, 2026

Summary

Bioactive peptides from natural sources offer diverse health benefits and therapeutic potential. Recent advancements in production, purification, and delivery systems are enhancing their efficacy and commercial viability for future foods and medicines.

Keywords:

Bioactive peptides bioavailability enzymatic hydrolysis functional foods nanocarrier drug delivery therapeutic applications

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Area of Science:

Biotechnology
Nutritional Science
Pharmacology

Background:

Bioactive peptides, derived from natural sources, exhibit numerous health benefits, including antihypertensive, antioxidant, and anticancer properties.
Their therapeutic and nutritional applications are gaining traction, driving research into efficient production and utilization.

Purpose of the Study:

To review recent molecular, biotechnological, and informatics-driven advancements in bioactive peptide research.
To synthesize 2024-2025 developments in production, bioassay optimization, and therapeutic translation of bioactive peptides.

Main Methods:

Enzymatic hydrolysis, microbial fermentation, chemical synthesis, and recombinant DNA technology for peptide production.
Ultrafiltration, chromatography, mass spectrometry, and electrophoresis for peptide purification and characterization.
Nanocarrier-based drug delivery systems, synthetic biology, and bioinformatics for overcoming limitations.

Main Results:

Significant progress in targeted peptide development and efficient production.
Overcoming challenges in purification, stability, and bioavailability through advanced technologies.
Expanding therapeutic possibilities and commercial viability of bioactive peptides.

Conclusions:

Bioactive peptides hold immense potential for next-generation functional foods and therapeutics.
Multidisciplinary research and sustainable sourcing are key to enhancing efficacy and market adoption.
Continued innovation promises to improve global health outcomes through bioactive peptide applications.