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Lipocalin-2 and Bone Loss: A Brief Review
Acta Orthopaedica Belgica
|April 3, 2026
Summary
Bone hormone lipocalin 2 (LCN2) influences bone remodeling and appetite. This research explores LCN2
Area of Science:
- Endocrinology
- Bone Biology
- Metabolism
Background:
- Bone is recognized as an endocrine organ.
- Osteoblasts secrete hormones, including lipocalin 2 (LCN2).
- LCN2 plays roles in bone metabolism and energy balance.
Purpose of the Study:
- To review literature on LCN2 secretion by osteoblasts.
- To examine LCN2's impact on bone remodeling.
- To investigate LCN2's systemic effects on appetite and energy homeostasis.
Main Methods:
- Comprehensive literature review.
- Analysis of experimental and clinical studies.
Main Results:
- LCN2 context-dependently regulates bone metabolism, promoting formation or resorption.
- LCN2 acts as an anorexigenic hormone, linking bone signals to appetite control.
- LCN2 influences systemic energy regulation.
Conclusions:
- LCN2 mediates skeletal health and systemic metabolism.
- LCN2's dual roles in bone and appetite suggest therapeutic potential.
- LCN2 may be a target for skeletal and metabolic disorders.
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