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Topographic CA1 input shapes subicular spatial coding
Yanjun Sun1, Daniel T Pederick2,3, Xiangmin Xu4,5
1Department of Neurobiology and Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Biorxiv : the Preprint Server for Biology
|April 3, 2026
Summary
Precise topography in hippocampal circuits organizes spatial maps in the subiculum. Disrupting this organization impairs boundary coding and network stability, highlighting its crucial role.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- The hippocampus exhibits topographic organization, but its functional importance is not fully understood.
- Spatial coding in the hippocampus is critical for navigation and memory.
Purpose of the Study:
- To investigate the functional significance of CA1-to-subiculum topographic projections.
- To determine how disrupted topography affects spatial coding and network dynamics in the subiculum.
Main Methods:
- Utilized latrophilin-2 conditional knockout mice to selectively disrupt CA1-to-subiculum projections.
- Analyzed the anatomical distribution of spatial coding in the subiculum.
- Assessed single-cell tuning, boundary vector coding, and long-term network stability.
Main Results:
- Disrupted topography altered the anatomical distribution of subicular spatial coding.
- Single-cell tuning properties were preserved despite topographic disruption.
- Selective impairment of boundary vector coding and long-term network stability was observed.
Conclusions:
- CA1 topographic inputs are essential for organizing subicular spatial maps.
- Precise topography provides a scaffold for subicular spatial dynamics and network stability.
