Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Foveated light-field compound imager.

Science advances·2026

Same author

Domain-adapted foundation model for automated cardiac CT substructure segmentation for thoracic radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026

Same author

Exploring the functional role of palmitoylation genes in clear cell renal cell carcinoma and their impact on tumor microenvironment.

BMC genomic data·2026

Same author

Evaluating age-dependent transmission and vaccination policy in Singapore's SARS-CoV-2 epidemic: A computational modelling approach.

Epidemics·2026

Same author

Host-Pathogen Network and Eco-Evolutionary Drivers of Avian Influenza Transmission in Wild Birds.

Ecology letters·2026

Same author

Transformer-based synthesis of 7 Tesla-like T1 contrast from routine clinical magnetic resonance imaging.

Medical physics·2026

Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026

Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026

Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026

Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026

Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026

Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 4, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Hydrogel Fiber Endomicroscopy.

Peng Chen, Keyi Han, Zijun Gao

Biorxiv : the Preprint Server for Biology

|April 3, 2026

Summary

This summary is machine-generated.

HYFEN, a novel hydrogel endomicroscopy platform, offers flexible, biocompatible, subcellular-scale fluorescence imaging. This breakthrough enhances minimally invasive diagnostics in delicate areas.

More Related Videos

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

Published on: May 5, 2023

Related Experiment Videos

Last Updated: Apr 4, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

Published on: May 5, 2023

Area of Science:

Biomedical Engineering
Optical Imaging
Materials Science

Background:

Multimode fibers are crucial for minimally invasive, high-resolution imaging in sensitive anatomical areas.
Conventional silica-based fibers face limitations like mode scrambling, restricted fields of view, and mechanical rigidity.
There is a need for advanced imaging platforms that overcome these challenges for improved diagnostic precision.

Purpose of the Study:

To introduce HYFEN, a hydrogel-based endomicroscopic imaging platform.
To demonstrate HYFEN's capability for flexible, biocompatible, and subcellular-scale fluorescence microscopy.
To address the limitations of silica-based fibers in minimally invasive imaging.

Main Methods:

Utilized hydrogel materials, adaptive optics, and pixel-wise image enhancement.
Developed precise mode threading for controlled light propagation.
Achieved rapid, diffraction-limited focusing at kilohertz speeds.
Integrated high-fidelity fluorescence signal acquisition.

Main Results:

HYFEN provides subcellular-scale fluorescence microscopy with high fidelity.
The platform demonstrates precise mode threading and rapid focusing capabilities.
Achieved enhanced fluorescence imaging under challenging fiber dimensions and bending conditions.
Overcame limitations of conventional silica-based fibers.

Conclusions:

HYFEN establishes a versatile platform for next-generation biointerfacing.
The technology enables advanced minimally invasive imaging in biomedical and clinical settings.
HYFEN offers superior flexibility and biocompatibility compared to existing modalities.