Jove
Visualize
Contact Us

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

627
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
627
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

616
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
616
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.2K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.2K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

480
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
480
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

964
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
964
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

1.5K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Cocktail-style multifunctional resuscitation fluids: Where are we now in 2026?

Journal of anesthesia and translational medicine·2026
Same author

Glottic-level, anesthesia machine-based high-frequency ventilation as an oxygenation bridge for short pediatric gastroscopy under intravenous anesthesia: a nine-patient case series.

Journal of anesthesia·2026
Same author

Growth history revealed by tree rings provides clues for the conservation of an endangered subtropical tree species.

Frontiers in plant science·2026
Same author

[Prenatal diagnosis of Fetal left-right asymmetry anomalies in a single-center cohort].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·2026
Same author

Near-Flat End-Tidal Carbon Dioxide During Mechanically Ventilated Cardiopulmonary Resuscitation in Pulmonary Atresia With Collateral-Dependent Pulmonary Blood Flow.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Characteristics of Bibliometric Analyses of the Complementary, Alternative, and Integrative Medicine Literature: A Scoping Review.

Journal of integrative and complementary medicine·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 4, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.9K

Future perspective on chronic kidney disease management.

Xiaomei Qiu1, Xueqin Ding2, Henry Liu3

  • 1Department of Anesthesiology, Chengdu First People's Hospital, Chengdu 610000, China.

Journal of Anesthesia and Translational Medicine
|April 3, 2026
PubMed
Summary

Sympathetic nervous system over-activation drives chronic kidney disease (CKD) progression. Thoracic epidural blockade offers a novel therapeutic approach for CKD management, potentially overcoming limitations of current treatments.

Keywords:
Chronic kidney diseaseRenal denervationSympathetic activityThoracic epidural blockade

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.4K
Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

8.0K

Related Experiment Videos

Last Updated: Apr 4, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.9K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

5.4K
Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

8.0K

Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Pain Management

Background:

  • Sympathetic nervous system over-activation is a key feature of chronic kidney disease (CKD).
  • Renal ischemia significantly contributes to the development and progression of CKD.
  • Current pharmacologic treatments for sympathetic over-activity in CKD face challenges like limited efficacy and adverse effects.

Purpose of the Study:

  • To review the pathophysiology of CKD and the role of the sympathetic nervous system.
  • To evaluate the limitations of existing pharmacologic treatments and renal denervation for CKD.
  • To explore thoracic epidural blockade as a novel therapeutic strategy for CKD management.

Main Methods:

  • Literature review focusing on CKD pathophysiology, sympathetic nervous system involvement, and therapeutic interventions.
  • Analysis of current pharmacologic strategies and renal denervation outcomes in CKD.
  • Exploration of thoracic epidural blockade's potential mechanisms and benefits in CKD.

Main Results:

  • Pharmacologic approaches and renal denervation show variable outcomes and risks in managing sympathetic over-activity in CKD.
  • Renal denervation may disrupt essential renal nervous system regulatory functions.
  • Thoracic epidural blockade presents a promising alternative by modulating sympathetic nervous system activity.

Conclusions:

  • Thoracic epidural blockade offers a novel therapeutic avenue for managing sympathetic nervous system over-activation in chronic kidney disease.
  • This approach may overcome the limitations associated with current pharmacologic treatments and renal denervation.
  • Further research is warranted to establish the efficacy and safety of thoracic epidural blockade in CKD patients.