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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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Cardiovascular complications in chronic active Epstein-Barr virus infection: a narrative review

Jing Xu1, Yunfeng Wei1, Lin Shi2

  • 1Department of Ultrasound, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.

Frontiers in Cardiovascular Medicine
|April 3, 2026
PubMed

Insights

Cardiovascular complications from chronic active Epstein-Barr virus (CAEBV) infection are rare but serious. This review summarizes patient data to improve understanding and management of these cardiac issues.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Cardiovascular involvement in chronic active Epstein-Barr virus (CAEBV) infection is an uncommon but severe complication.
  • Existing data on managing CAEBV-associated cardiovascular damage is limited.
  • This review addresses the need for comprehensive information on CAEBV's cardiac impact.

Purpose of the Study:

  • To summarize clinical characteristics, pathological features, diagnostic approaches, and treatment strategies for CAEBV-related cardiac damage.
  • To enhance awareness of cardiovascular complications associated with CAEBV infection.
  • To provide insights for clinical management of these rare conditions.

Main Methods:

  • A narrative review was conducted.
  • Searched PubMed, Embase, Web of Science, CNKI, CQVIP, and Wanfang Data databases.
  • Collected data on CAEBV infection with cardiovascular involvement.

Main Results:

  • 32 articles reporting 57 patients with CAEBV-associated cardiovascular complications were identified.
  • Median age was 11 years, with 66.7% children and 33.3% adults.
  • Coronary artery lesions, arrhythmias, and valvular issues were common in children; heart failure and pulmonary hypertension were more prevalent in adults.

Conclusions:

  • Cardiovascular involvement in CAEBV infection poses significant diagnostic and therapeutic challenges.
  • Systematic evaluation is crucial for timely intervention and surveillance.
  • Further research is needed to understand pathogenic mechanisms and optimize treatment due to poor prognosis.
Abstract

Keywords:
cardiogramcardiovascular complicationchronic active Epstein–Barr viruscoronary artery lesionspulmonary arterial hypertension

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