Related Experiment Video
Updated: Jul 7, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
Association between sleep quality and cancer-related cognitive impairment in patients with cancer: a meta-analysis
Zhenjuan Dang1,2, Meirong Fan2, Yao Zhang2
1School of Nursing, Faculty of Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Objectives:
This meta-analysis aimed to systematically evaluate and synthesize existing evidence to elucidate the association between sleep quality and cancer-related cognitive impairment (CRCI).
Methods:
PubMed, Embase, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), China Biology Medicine Disc (CBM), Wanfang data, and the VIP Journal Resource Integration Service Platform (VIP) were systematically searched inception to July 2025. The quality of the literature was evaluated using the Newcastle-Ottawa Scale and the Joanna Briggs Institute Cross-sectional Study Evaluation Checklist. The effect size r was transformed into Fisher's z-values for statistical analysis. The combined analysis was performed using Fisher's z-values and its standard error, and then the combined z-values were converted back to r for the discussion of the results. Statistical analyses were performed using Stata v.18.0.
Results:
A total of 4,037 articles were retrieved, and 13 articles (2,908 participants) were selected for further analysis. The meta-analysis based on the correlation coefficient r revealed a significant association between sleep quality and CRCI, with a correlation coefficient of r = -0.44 (95% CI: -0.55, -0.32). Sensitivity analysis confirmed the robustness of the (r = -0.47 to -0.40), and publication bias was not detected (p = 0.410). A supplementary meta-analysis of six studies using standardized regression coefficients further supported this association (β = -0.28, 95% CI: -0.34 to -0.22).
Conclusion:
Studies have found a moderate negative correlation between sleep quality and CRCI, suggesting that poorer sleep quality is associated with more severe cognitive impairment.
Systematic Review Registration:
PROSPERO RD420251090655.
More Related Videos
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Related Concept Videos
Cancer Survival Analysis
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Insomnia
Multiple factors contribute...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Psychoneuroimmunology: Diabetes and Cancer