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Burden of Injection Drug Use-Related Infection Hospitalizations in Tennessee, 2016-2023.

Emily R Moore1, Anastasia N Cajigal2, Amber J Coyne2

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Summary
This summary is machine-generated.

Injection drug use-related infections led to over 79,000 hospitalizations in Tennessee from 2016-2023, costing billions. Expanding harm reduction programs like syringe services can reduce this burden.

Keywords:
injection drug useinjection-related infectionsevere bacterial infectionsyndemic

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Health Services Research

Background:

  • Injection drug use is a significant driver of serious infections and morbidity.
  • Harm reduction programs, including syringe services, are crucial for mitigating these health risks.
  • Understanding the burden of injection-related infections is vital for public health planning and resource allocation.

Purpose of the Study:

  • To quantify the hospitalization burden of injection-related infections in Tennessee from 2016 to 2023.
  • To identify demographic and geographic patterns of these hospitalizations.
  • To inform strategies for expanding syringe service programs (SSPs) to reduce infection rates.

Main Methods:

  • Retrospective analysis of the Tennessee Hospital Discharge Data System (2016-2023).
  • Inclusion criteria based on ICD-10 codes for drug use and injection-related infections.
  • Calculation of hospitalization rates, costs, length of stay, and demographic characteristics.

Main Results:

  • Injection-related infections accounted for 79,276 hospitalizations (1.6% of total), costing $5.38 billion.
  • Bacteremia/sepsis was the most common diagnosis, followed by skin/soft tissue and endocarditis.
  • Eastern Tennessee showed the highest hospitalization rates, peaking in 2018 and plateauing thereafter.

Conclusions:

  • Injection-related infection hospitalization rates have plateaued since 2018.
  • Expanded access to syringe service programs, especially in eastern Tennessee, is recommended to prevent costly hospitalizations.
  • Public health interventions targeting harm reduction are essential for managing injection drug use-related infections.