Related Experiment Video
Updated: Apr 4, 2026
Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
Application of bundle management strategies in reducing local sterile abscesses following leuprolide acetate
Jinfang Yuan1, Linghui Li1, Ying Zhao1
1Department of Pediatric, Peking University Third Hospital, Beijing, China.
Insights
Bundle management strategies significantly reduced sterile abscesses from leuprolide acetate injections in pediatric patients. This quality improvement initiative enhanced patient care and adherence, demonstrating its clinical value.
Area of Science:
- Pediatric Endocrinology
- Quality Improvement in Healthcare
- Pharmacological Treatment Complications
Background:
- Local sterile abscesses are a known complication of leuprolide acetate microsphere injections.
- Identifying risk factors and implementing targeted strategies are crucial for mitigating adverse events.
- Central precocious puberty (CPP) management requires long-term treatment with injectable medications.
Purpose of the Study:
- To evaluate the effectiveness of bundle management strategies in reducing sterile abscesses after leuprolide acetate microsphere injections.
- To assess the impact of a comprehensive quality improvement program on patient outcomes and healthcare processes.
- To determine if standardized protocols and enhanced training improve safety in pediatric endocrine therapy.
Main Methods:
- A single-center, intervention evaluation with a historical control study design.
- Comparison of sterile abscess incidence between a control group (conventional management) and an intervention group (bundle management strategies).
- Bundle management included staff training, standardized procedures, tools, education, and follow-up for leuprolide acetate microsphere administration.
Main Results:
- The incidence of sterile abscesses decreased from 5.1% (by patient) and 3.2‰ (by injection) in the control group to 0.6% (by patient) and 0.4‰ (by injection) in the intervention group.
- Statistical analysis showed a significant reduction in sterile abscesses in the intervention group (P < 0.001).
- The intervention group demonstrated improved nurses' operational proficiency and professional competence.
Conclusions:
- Bundle management strategies are highly effective in reducing local sterile abscesses following leuprolide acetate microsphere injections.
- This approach enhances nursing standards, alleviates patient suffering, and improves treatment adherence.
- The findings support the clinical adoption of bundle management strategies for leuprolide acetate administration.
Objective:
To investigate the effect of bundle management strategies on reducing the incidence of local sterile abscesses following leuprolide acetate microsphere injections.
Methods:
A single-center, intervention evaluation with a historical control study was conducted. Female children treated with leuprolide acetate microspheres for central precocious puberty (CPP) at the Pediatric Outpatient Department of Peking University Third Hospital from January 2016 to December 2024 were included as study participants. Patients from January 2016 to December 2018 served as the control group (277 individuals, 5,023 injections), during which high-risk factors for sterile abscesses were identified and bundle improvement strategies were formulated for continuous quality improvement. Patients from January 2019 to December 2024 were assigned to the intervention group (994 individuals, 13,498 injections). The control group received conventional management protocols, while the intervention group implemented a bundle management scheme encompassing medical and nursing staff training, standardized procedures, use of standardized tools, health education, and follow-up management. The incidence of local sterile abscesses was compared between the two groups.
Results:
After implementation of the bundle management strategies, the incidence of sterile abscesses in the control group was 5.1% (14/277) by patient count and 3.2‰ (16/5,023) by injection count, which decreased to 0.6% (6/994) and 0.4‰ (6/13,498) in the intervention group, respectively, with statistically significant intergroup differences (P < 0.001 for both).
Conclusion:
Implementation of bundle management strategies significantly reduces the incidence of local sterile abscesses after leuprolide acetate microsphere injections, enhances nurses' standardized operational proficiency and professional competence, alleviates patient suffering, improves treatment adherence, and warrants clinical adoption.
