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TREM2 in Alzheimer's disease: A global bibliometric analysis of research evolution and therapeutic implications
Linjing Cui1, Zhang Yue2, Chen Sun3
1Department of Clinical Laboratory, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China.
Background:
Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor genetically linked to Alzheimer's disease (AD) and increasingly recognized as a key regulator of neuroinflammation, yet its global research landscape in AD remains unclear.
Objective:
In the central nervous system, TREM2 expressed on microglia is closely related to the occurrence and development of AD and has been extensively studied in recent years. However, there is still a lack of bibliometric analysis regarding TREM2 and AD.
Methods:
We searched in the Web of Science Core Collection (WoSCC) for articles published from January 1, 2000, to September 30, 2024. After a thorough screening process, we selected relevant information regarding TREM2 and AD. Subsequently, a comprehensive analysis was conducted on a total of 944 publications. The analysis utilized GraphPad Prism 9, CiteSpace6.1.6, VOSviewer1.6.19, the Online Analysis Platform of Literature Metrology, GeneMANIA and Metascape.
Results:
A total of 944 publications from 2000 to 2024 met the inclusion criteria for this analysis. Over this period, research activity in TREM2 and AD has shown a consistent upward trend, with notable peaks in 2021 and 2022. The United States and China lead in the number of publications, with Washington University being the top research institution. Neurobiology of Aging is the most frequently cited journal in this field. Research has focused on key areas like molecular biology, genetics, and neuroimmunology. Critical keywords include microglia, inflammation, and genetic variants, while recent studies highlight emerging topics such as protein interactions, neurodegeneration, and cognitive impairment.
Conclusions:
This study employs advanced bibliometric analysis tools and visualization techniques to clearly present the major research themes, development trends, and prospects of TREM2 in AD.
Insights
This bibliometric analysis reveals a growing research focus on Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) in Alzheimer's disease (AD). Key areas include neuroinflammation, genetics, and microglia, with emerging trends in protein interactions and cognitive impairment.
Area of Science:
- Neuroscience
- Immunology
- Genetics
Background:
- Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a microglial receptor genetically linked to Alzheimer's disease (AD).
- TREM2 is recognized as a key regulator of neuroinflammation in the central nervous system.
- The global research landscape of TREM2 in AD requires comprehensive bibliometric analysis.
Purpose of the Study:
- To conduct a bibliometric analysis of TREM2 research in Alzheimer's disease.
- To identify major research themes, development trends, and prospects.
- To visualize the scientific landscape of TREM2 and AD research.
Main Methods:
- Bibliometric analysis of 944 publications from 2000-2024 in the Web of Science Core Collection.
- Utilized tools including GraphPad Prism 9, CiteSpace, VOSviewer, and Metascape.
- Screened and selected relevant articles focusing on TREM2 and AD.
Main Results:
- Research on TREM2 and AD shows a consistent upward trend, peaking in 2021-2022.
- The United States and China are leading in publications, with Washington University as a top institution.
- Key research areas include molecular biology, genetics, and neuroimmunology, with keywords like microglia, inflammation, and genetic variants.
Conclusions:
- This study provides a clear overview of TREM2 research in AD using bibliometric analysis.
- Identified major research themes and emerging topics such as protein interactions and cognitive impairment.
- Highlights the evolving trends and future prospects in TREM2-related AD research.
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