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Case Report: Marchiafava-Bignami disease: anti-parietal cell antibodies as a potential etiological factor in a novel

Junhao Zhang1, Lizhen Wang1, Shuangfeng Yang2

  • 1Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Frontiers in Molecular Biosciences
|April 3, 2026
PubMed

Insights

Marchiafava-Bignami disease (MBD) may be linked to cobalamin deficiency from anti-parietal cell antibodies (APCA). Consider APCA screening and vitamin B12 assessment in MBD diagnosis, particularly when thiamine deficiency is absent.

Area of Science:

  • Neurology
  • Internal Medicine
  • Nutritional Science

Background:

  • Marchiafava-Bignami disease (MBD) is a rare neurological condition.
  • It is primarily linked to chronic alcohol use and thiamine deficiency.
  • The role of cobalamin deficiency due to anti-parietal cell antibodies (APCA) in MBD is not well understood.
Keywords:
anti-parietal cell antibodiesdemyelinationmarchiafava-Bignami disease (MBD)necrosisvitamin B12 deficiency

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